ADGRA3

Across TCGA patient cohorts, ADGRA3 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRA3-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and Chk2_pT68. Each is linked with ADGRA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRA3-to-partner and partner-to-ADGRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADGRA3-low versus ADGRA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRA3→partner) and Y-score (partner→ADGRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.596	-1.807	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.080	+2.467	.001	.011	2	4
UCEC	Chk2_pT68 →	-0.164	-2.973	.003	<.001	3	3
UCEC	EGFR_pY1068 →	-0.220	-1.662	.003	.010	3	2
UCEC	JNK2 →	+0.244	+2.050	<.001	<.001	3	2
UCEC	PDCD4 →	-0.459	-1.584	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ATM by ADGRA3 expression — UCEC

Explore this box plot interactively →