ADGRA3

Across TCGA pan-cancer cohorts, ADGRA3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ADGRA3 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ADGRA3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADGRA3 expression acts as an unfavorable survival marker, although some lineages such as UCS and COAD show a favorable association.

ACC, KICH, and UCS are the cancer types where ADGRA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.337	0.805	<.001	69	view →
KICH	DFS	Median	All	0.644	1.000	.002	60	view →
UCS	DFS	Median	III,IV	0.462	0.126	.005	44	view →
COAD	OS	Quartile	II,III,IV	0.877	0.595	.003	31	view →
LUSC	DFS	Median	III,IV	0.553	0.773	.001	23	view →
KIRC	OS	Median	All	0.922	0.837	.005	22	view →
SCLC	OS	Median	II,III,IV	0.524	0.732	.014	21	view →
THCA	OS	Median	All	0.963	1.000	.012	21	view →
CESC	DFS	Tertile	All	0.609	0.792	.003	18	view →
SARC	OS	Tertile	All	0.624	0.882	<.001	17	view →
GBM	OS	Median	All	0.443	0.231	.015	12	view →
LUAD	DFS	Tertile	II,III,IV	0.431	0.661	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ADGRA3–ACC (DFS)

Open the ACC breakdown →