ADGRA3

Across TCGA cell cohorts, ADGRA3 mutation is significantly associated with the RNA expression of many other genes, with 512 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRA3-associated genes across cancer lineages are OR10W1, OR10T2, and NYX. Each is linked with ADGRA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRA3-to-partner and partner-to-ADGRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by ADGRA3-low versus ADGRA3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRA3→partner) and Y-score (partner→ADGRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10W1 →	+0.008	+4.196	<.001	.006	3	2
BREAST	OR10T2 →	+0.110	+4.196	<.001	.006	3	2
LUNG_NSCLC_LUAD	NYX →	+0.278	+3.605	<.001	.007	3	2
LARGE_INTESTINE	SPEM3 →	+0.006	+1.932	.003	.007	3	2
LIVER	SPACA1 →	+0.022	+4.459	<.001	.001	3	1
LIVER	PYHIN1 →	+0.012	+3.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 512 associations by consensus.

OR10W1 by ADGRA3 expression — BREAST

Explore this box plot interactively →