ADGRA2

Across TCGA pan-cancer cohorts, ADGRA2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ADGRA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADGRA2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ADGRA2 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where ADGRA2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRA2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.589	<.001	11	view →
LSCC	Male	All	−0.431	<.001	8	view →
LUAD	Female	All	−0.548	<.001	7	view →
PDAC	Male	All	−0.377	.012	4	view →
OV	All	All	−1.417	<.001	2	view →
COAD	All	All	+0.455	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ADGRA2–HNSC

Open the HNSC breakdown →