ADGRA2

Across TCGA pan-cancer cohorts, ADGRA2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ADGRA2 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ADGRA2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADGRA2 expression acts as an unfavorable survival marker, although some lineages such as UCS and UCEC show a favorable association.

KIRP, BLCA, and UVM are the cancer types where ADGRA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.417	0.757	<.001	133	view →
BLCA	OS	Tertile	All	0.527	0.709	<.001	77	view →
UVM	DFS	Tertile	All	0.295	0.633	.001	67	view →
MESO	OS	Quartile	II,III,IV	0.273	0.559	.003	54	view →
UCS	DFS	Quartile	II,III,IV	0.655	0.147	.005	52	view →
UCEC	DFS	Median	III,IV	0.857	0.724	.013	40	view →
KIRC	DFS	Median	All	0.744	0.516	.004	33	view →
LUAD	OS	Tertile	II,III,IV	0.717	0.460	.002	27	view →
HNSC	DFS	Median	IV	0.658	0.489	.003	24	view →
OV	OS	Quartile	III,IV	0.339	0.464	.010	18	view →
KICH	DFS	Tertile	II,III,IV	0.570	1.000	.018	17	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ADGRA2–KIRP (OS)

Open the KIRP breakdown →