ADGRA2

Across TCGA patient cohorts, ADGRA2 mutation is significantly associated with the RNA expression of many other genes, with 2,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRA2-associated genes across cancer lineages are HTR3D, LINC01848, and RN7SKP60. Each is linked with ADGRA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRA2-to-partner and partner-to-ADGRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR3D grouped by ADGRA2-low versus ADGRA2-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRA2→partner) and Y-score (partner→ADGRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	HTR3D →	+0.101	+5.189	<.001	.006	3	3
SKCM	LINC01848 →	+0.134	+2.823	<.001	.006	3	3
PRAD	RN7SKP60 →	+0.205	+5.993	.002	.002	3	3
COAD	MIR8055 →	+1.101	+3.244	<.001	.001	3	3
UCEC	RPS29P32 →	+0.273	+1.763	.001	.007	3	3
SKCM	MIR302A →	+0.414	+2.630	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,450 associations by consensus.

HTR3D by ADGRA2 expression — SCLC

Explore this box plot interactively →