ADGRA2

Across TCGA patient cohorts, ADGRA2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRA2-associated genes across cancer lineages are Dvl3, INPP4B, and Src_pY527. Each is linked with ADGRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRA2-to-partner and partner-to-ADGRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dvl3 grouped by ADGRA2-low versus ADGRA2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRA2→partner) and Y-score (partner→ADGRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Dvl3 →	+0.160	+3.000	.041	.035	3	2
UCEC	INPP4B →	-0.245	-2.222	.028	.009	3	2
UCEC	Src_pY527 →	-0.312	-1.690	.036	.042	3	2
UCEC	ATM →	-0.671	-2.459	<.001	<.001	3	2
LUAD	4E-BP1_pS65 →	+0.180	+3.321	.009	.010	3	1
LUSC	4E-BP1_pT37_T46 →	+0.588	+2.816	.047	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Dvl3 by ADGRA2 expression — LUAD

Explore this box plot interactively →