ADGRA2

Across TCGA cell cohorts, ADGRA2 mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRA2-associated genes across cancer lineages are KRTAP4-6, TARM1, and TBL1Y. Each is linked with ADGRA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRA2-to-partner and partner-to-ADGRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP4-6 grouped by ADGRA2-low versus ADGRA2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRA2→partner) and Y-score (partner→ADGRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KRTAP4-6 →	+0.075	+2.695	.003	.009	3	2
URINARY_TRACT	TARM1 →	+0.020	+4.087	<.001	.009	3	1
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
STOMACH	OR52W1 →	+0.080	+3.459	.006	.003	3	1
STOMACH	OR2A2 →	+0.057	+3.691	<.001	.002	3	1
SKIN	SLC10A2 →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

KRTAP4-6 by ADGRA2 expression — STOMACH

Explore this box plot interactively →