ADGB

Across TCGA cell cohorts, ADGB mutation is significantly associated with the RNA expression of many other genes, with 1,979 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGB-associated genes across cancer lineages are C22orf46, NKX2-6, and OR3A1. Each is linked with ADGB in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGB-to-partner and partner-to-ADGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C22orf46 grouped by ADGB-low versus ADGB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGB→partner) and Y-score (partner→ADGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C22orf46 →	+1.282	+3.949	<.001	<.001	3	3
BLOOD_Leukemia	NKX2-6 →	+0.337	+4.201	<.001	.001	3	2
BLOOD_Lymphoma	OR3A1 →	+0.962	+3.343	<.001	<.001	3	2
BLOOD_Lymphoma	MYMK →	+0.029	+3.472	<.001	.002	3	2
BLOOD_Lymphoma	LRRC3C →	+0.070	+3.426	.007	.007	3	2
BLOOD_Lymphoma	CENPVL3 →	+0.019	+3.342	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,979 associations by consensus.

C22orf46 by ADGB expression — LARGE_INTESTINE

Explore this box plot interactively →