ADCY9

Across TCGA patient cohorts, ADCY9 mutation is significantly associated with the RNA expression of many other genes, with 7,687 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY9-associated genes across cancer lineages are SEC13, STIP1, and NDUFS5. Each is linked with ADCY9 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADCY9-to-partner and partner-to-ADCY9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC13 grouped by ADCY9-low versus ADCY9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY9→partner) and Y-score (partner→ADCY9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC13 →	+0.396	+1.725	<.001	<.001	3	4
UCEC	STIP1 →	+0.448	+2.032	<.001	<.001	3	4
UCEC	NDUFS5 →	+0.258	+1.262	.003	.001	3	4
STAD	MRM3 →	+0.503	+2.840	<.001	.001	3	4
UCEC	THOP1 →	+0.576	+2.212	<.001	<.001	3	4
UCEC	CKS1B →	+0.418	+1.450	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,687 associations by consensus.

SEC13 by ADCY9 expression — UCEC

Explore this box plot interactively →