ADCY8

Across TCGA pan-cancer cohorts, ADCY8 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ADCY8 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ADCY8 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ADCY8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, CESC, and READ are the cancer types where ADCY8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.877	0.611	<.001	34	view →
CESC	OS	Median	IV	0.091	0.593	<.001	12	view →
READ	DFS	Median	III,IV	0.255	0.757	.008	6	view →
SARC	DFS	Median	All	0.159	0.594	.019	6	view →
SKCM	DFS	Median	II,III,IV	0.786	0.643	.020	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ADCY8–UCEC (DFS)

Open the UCEC breakdown →