ADCY8

Across TCGA pan-cancer cohorts, ADCY8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ADCY8’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ADCY8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADCY8 is over-expressed in tumor, although a few such as LUAD and UCEC show the opposite, repressed pattern.

THCA, LUAD, and UCEC are the cancer types where ADCY8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADCY8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+2.615	<.001	11	view →
LUAD	Male	II,III,IV	−1.587	<.001	11	view →
UCEC	All	All	−1.775	<.001	6	view →
LUSC	Female	All	−1.347	<.001	6	view →
KIRC	Male	All	+0.679	<.001	6	view →
KICH	All	All	−0.261	<.001	6	view →
LIHC	Male	All	+0.560	.017	4	view →
HNSC	All	All	−0.216	.005	4	view →
BRCA	All	All	−0.130	.003	4	view →
PRAD	All	All	−0.240	.009	2	view →
KIRP	All	IV	−0.185	.034	2	view →
STAD	All	All	−0.045	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ADCY8–THCA

Open the THCA breakdown →