ADCY8

Across TCGA patient cohorts, ADCY8 protein abundance is significantly associated with the RNA expression of many other genes, with 1,502 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ADCY8-associated genes across cancer lineages are PRODH, GCAT, and TIMP3. Each is linked with ADCY8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY8-to-partner and partner-to-ADCY8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADCY8 versus PRODH in GBM, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY8→partner) and Y-score (partner→ADCY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+1.069	+0.488	<.001	.001	3	1
GBM	GCAT →	+0.487	+0.511	.002	.003	3	1
GBM	TIMP3 →	+0.736	+0.463	<.001	.002	3	1
GBM	ACO2 →	+0.231	+0.333	.009	.002	3	1
GBM	TRIM9 →	+0.700	+0.421	<.001	<.001	3	1
GBM	ZFYVE21 →	+0.368	+0.333	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,502 associations by consensus.

ADCY8 vs PRODH — GBM

Explore this scatter interactively →