ADCY8

Across TCGA patient cohorts, ADCY8 mutation is significantly associated with the RNA expression of many other genes, with 7,177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY8-associated genes across cancer lineages are TIMM44, RPF1, and TPI1. Each is linked with ADCY8 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADCY8-to-partner and partner-to-ADCY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM44 grouped by ADCY8-low versus ADCY8-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY8→partner) and Y-score (partner→ADCY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TIMM44 →	+0.490	+2.371	<.001	<.001	3	6
STAD	RPF1 →	+0.355	+2.889	<.001	.001	3	6
STAD	TPI1 →	+0.414	+2.338	.002	<.001	3	6
UCEC	CDKN3 →	+0.604	+1.451	<.001	<.001	3	6
SCLC	RTKN2 →	+0.765	+2.622	.001	.003	3	5
SKCM	PHF7 →	+0.255	+1.221	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,177 associations by consensus.

TIMM44 by ADCY8 expression — STAD

Explore this box plot interactively →