ADCY8

Across TCGA patient cohorts, ADCY8 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY8-associated genes across cancer lineages are Di-Ras3, CD31, and p70-S6K. Each is linked with ADCY8 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADCY8-to-partner and partner-to-ADCY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by ADCY8-low versus ADCY8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY8→partner) and Y-score (partner→ADCY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Di-Ras3 →	-0.164	-2.584	.012	.010	3	4
LUSC	CD31 →	-0.165	-1.668	.005	.021	3	3
STAD	p70-S6K →	+0.213	+3.342	.020	.004	3	3
STAD	Rictor →	-0.837	-2.415	.021	.003	3	3
STAD	S6 →	+0.401	+2.459	.007	.018	3	3
STAD	Bap1-c-4 →	+0.265	+3.169	.045	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

Di-Ras3 by ADCY8 expression — COAD

Explore this box plot interactively →