ADCY8

Across TCGA cell cohorts, ADCY8 mutation is significantly associated with the RNA expression of many other genes, with 486 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY8-associated genes across cancer lineages are SLCO1B3, CCER1, and DPRX. Each is linked with ADCY8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY8-to-partner and partner-to-ADCY8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1B3 grouped by ADCY8-low versus ADCY8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY8→partner) and Y-score (partner→ADCY8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1B3 →	+1.907	+3.321	.002	.003	3	3
CNS	CCER1 →	+0.012	+4.754	<.001	.005	3	2
CNS	DPRX →	+0.050	+4.321	<.001	.009	3	2
SKIN	GSTZ1 →	+0.591	+3.364	.003	.002	3	2
SKIN	RAB5IF →	-0.524	-3.169	.008	.009	3	2
SKIN	USP45 →	+0.442	+3.169	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

SLCO1B3 by ADCY8 expression — LARGE_INTESTINE

Explore this box plot interactively →