ADCY7

Across TCGA cell cohorts, ADCY7 mutation is significantly associated with the RNA expression of many other genes, with 782 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY7-associated genes across cancer lineages are PRR23D2, FBXL4, and STXBP3. Each is linked with ADCY7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY7-to-partner and partner-to-ADCY7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23D2 grouped by ADCY7-low versus ADCY7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY7→partner) and Y-score (partner→ADCY7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRR23D2 →	+0.193	+3.459	<.001	.001	3	2
LARGE_INTESTINE	FBXL4 →	+0.637	+2.459	<.001	.003	3	2
LARGE_INTESTINE	STXBP3 →	+0.419	+3.087	.003	.006	3	2
LARGE_INTESTINE	DCLRE1B →	+0.455	+2.743	.009	.001	3	2
LARGE_INTESTINE	SLC17A5 →	+0.760	+2.743	<.001	.001	3	2
LARGE_INTESTINE	PPP1R9A →	+1.282	+3.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 782 associations by consensus.

PRR23D2 by ADCY7 expression — BLOOD_Leukemia

Explore this box plot interactively →