ADCY6

Across TCGA patient cohorts, ADCY6 mutation is significantly associated with the RNA expression of many other genes, with 4,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY6-associated genes across cancer lineages are SKA1, EIF3I, and GCAT. Each is linked with ADCY6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADCY6-to-partner and partner-to-ADCY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ADCY6-low versus ADCY6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY6→partner) and Y-score (partner→ADCY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.766	+1.970	<.001	<.001	3	4
UCEC	EIF3I →	+0.266	+1.776	<.001	<.001	3	4
UCEC	GCAT →	+0.508	+1.584	<.001	<.001	3	4
UCEC	AUNIP →	+0.565	+1.584	<.001	<.001	3	4
UCEC	COX15 →	+0.406	+3.375	<.001	<.001	3	3
UCEC	SLC25A4 →	+0.454	+1.776	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

SKA1 by ADCY6 expression — UCEC

Explore this box plot interactively →