ADCY6

Across TCGA patient cohorts, ADCY6 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY6-associated genes across cancer lineages are 4E-BP1_pT70, TSC1, and FASN. Each is linked with ADCY6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY6-to-partner and partner-to-ADCY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by ADCY6-low versus ADCY6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY6→partner) and Y-score (partner→ADCY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT70 →	+0.095	+1.263	.006	.019	3	3
COAD	TSC1 →	-0.503	-2.991	<.001	.036	3	3
STAD	FASN →	+0.376	+2.321	.045	.034	3	2
STAD	FoxM1 →	+0.288	+3.201	.015	.009	3	2
STAD	Rictor_pT1135 →	-0.167	-2.321	.015	.034	3	2
STAD	Cyclin-E2 →	+0.216	+3.480	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

4E-BP1_pT70 by ADCY6 expression — UCEC

Explore this box plot interactively →