ADCY6

Across TCGA cell cohorts, ADCY6 mutation is significantly associated with the RNA expression of many other genes, with 1,132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY6-associated genes across cancer lineages are MYO1B, EID2, and R3HDM1. Each is linked with ADCY6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY6-to-partner and partner-to-ADCY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO1B grouped by ADCY6-low versus ADCY6-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY6→partner) and Y-score (partner→ADCY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYO1B →	+1.755	+3.259	.002	.006	3	2
BLOOD_Leukemia	EID2 →	+0.526	+3.199	.008	.007	3	2
BLOOD_Leukemia	R3HDM1 →	+0.560	+3.199	.008	.007	3	2
LARGE_INTESTINE	SEPTIN3 →	+0.971	+2.129	.005	.007	3	2
LARGE_INTESTINE	JOSD1 →	+0.508	+3.459	.003	.001	3	2
LARGE_INTESTINE	TTC33 →	+0.565	+2.743	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,132 associations by consensus.

MYO1B by ADCY6 expression — BLOOD_Leukemia

Explore this box plot interactively →