ADCY6

Across TCGA cell cohorts, ADCY6 mutation is significantly associated with the mutation status of many other genes, with 4,886 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY6-associated genes across cancer lineages are PNPLA6, GPATCH8, and BCORL1. Each is linked with ADCY6 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADCY6-to-partner and partner-to-ADCY6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNPLA6 grouped by ADCY6-low versus ADCY6-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY6→partner) and Y-score (partner→ADCY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PNPLA6 →	+5.115	+5.115	.005	.005	1	5
OVARY	GPATCH8 →	+2.977	+4.273	.006	.006	1	5
BLOOD_Lymphoma	BCORL1 →	+3.845	+4.074	<.001	<.001	1	5
OVARY	PLCH2 →	+4.562	+5.217	<.001	<.001	1	5
OVARY	ITPR1 →	+3.562	+4.684	.002	.002	1	5
OVARY	SCN4A →	+4.562	+5.217	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,886 associations by consensus.

PNPLA6 by ADCY6 expression — PANCREAS

Explore this box plot interactively →