ADCY5

Across TCGA patient cohorts, ADCY5 mutation is significantly associated with the RNA expression of many other genes, with 6,891 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY5-associated genes across cancer lineages are CCNB2, HASPIN, and FBXO5. Each is linked with ADCY5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADCY5-to-partner and partner-to-ADCY5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCNB2 grouped by ADCY5-low versus ADCY5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY5→partner) and Y-score (partner→ADCY5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCNB2 →	+0.605	+2.209	<.001	<.001	3	5
UCEC	HASPIN →	+0.805	+2.209	<.001	<.001	3	5
SKCM	FBXO5 →	+0.507	+1.669	.005	.007	3	5
COAD	PIMREG →	+0.699	+3.087	<.001	<.001	3	5
SKCM	CDCA8 →	+0.697	+2.128	<.001	.009	3	5
COAD	KIF11 →	+0.687	+3.720	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,891 associations by consensus.

CCNB2 by ADCY5 expression — UCEC

Explore this box plot interactively →