ADCY5

Across TCGA pan-cancer cohorts, ADCY5 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ADCY5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ADCY5 RNA is repressed in tumor relative to normal tissue. In most cancer types ADCY5 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and THCA are the cancer types where ADCY5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADCY5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−2.332	<.001	12	view →
BLCA	Male	IV	−4.352	<.001	11	view →
THCA	All	II,III,IV	−0.464	<.001	9	view →
KIRP	Male	III,IV	−1.357	.001	8	view →
UCEC	All	All	−2.536	<.001	6	view →
BRCA	All	All	−1.935	<.001	6	view →
LUAD	Female	III,IV	−1.105	<.001	6	view →
READ	All	All	−2.523	<.001	5	view →
KICH	All	All	−1.554	<.001	5	view →
STAD	All	All	−1.513	.001	5	view →
LUSC	All	All	−0.502	.009	4	view →
CHOL	All	All	+1.903	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ADCY5–COAD

Open the COAD breakdown →