ADCY5

Across TCGA patient cohorts, ADCY5 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ADCY5-associated genes across cancer lineages are p90 RSK, Cyclin-E2, and MSH6. Each is linked with ADCY5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADCY5-to-partner and partner-to-ADCY5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by ADCY5-low versus ADCY5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY5→partner) and Y-score (partner→ADCY5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK →	+0.293	+3.584	<.001	.002	3	4
STAD	Cyclin-E2 →	+0.208	+2.342	<.001	.016	3	4
LUAD	MSH6 →	+0.325	+2.832	.027	.034	3	3
STAD	Bad_pS112 →	-0.188	-2.563	.032	.010	3	3
STAD	Claudin-7 →	+0.842	+2.321	.002	.032	3	3
UCEC	MEK1 →	+0.350	+2.201	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

p90 RSK by ADCY5 expression — SKCM

Explore this box plot interactively →