ADCY5

Across TCGA cell cohorts, ADCY5 mutation is significantly associated with the RNA expression of many other genes, with 920 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADCY5-associated genes across cancer lineages are LYG1, ZNF232, and PHF5A. Each is linked with ADCY5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY5-to-partner and partner-to-ADCY5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by ADCY5-low versus ADCY5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY5→partner) and Y-score (partner→ADCY5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.686	+2.743	.006	.001	3	3
LARGE_INTESTINE	ZNF232 →	+0.679	+3.087	.002	.006	3	3
LARGE_INTESTINE	PHF5A →	+0.578	+2.743	<.001	.001	3	2
LARGE_INTESTINE	BLOC1S6 →	+0.413	+3.082	.004	.007	3	2
LARGE_INTESTINE	OSBP →	+0.503	+3.237	.007	.003	3	2
LARGE_INTESTINE	RNGTT →	+0.447	+2.043	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 920 associations by consensus.

LYG1 by ADCY5 expression — LARGE_INTESTINE

Explore this box plot interactively →