ADCY3

Across TCGA patient cohorts, ADCY3 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,875 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ADCY3-associated proteins across cancer lineages are GBF1, MSH2, and MSH6. Each is linked with ADCY3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADCY3-to-partner and partner-to-ADCY3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADCY3 versus GBF1 in BRCA, with a Pearson correlation of -0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY3→partner) and Y-score (partner→ADCY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBF1 →	-0.199	-0.521	<.001	<.001	3	5
LSCC	MSH2 →	+0.575	+0.863	<.001	<.001	3	5
LSCC	MSH6 →	+0.650	+0.866	<.001	<.001	3	5
BRCA	HID1 →	-0.617	-0.514	<.001	<.001	3	5
OV	HID1_S593 →	-0.948	-0.893	<.001	<.001	3	5
GBM	PRIM2 →	+0.386	+0.272	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,875 associations by consensus.

ADCY3 vs GBF1 — BRCA

Explore this scatter interactively →