ADCY3

Across TCGA pan-cancer cohorts, ADCY3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ADCY3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADCY3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADCY3 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where ADCY3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADCY3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.376	<.001	12	view →
COAD	All	IV	+1.824	<.001	11	view →
KIRC	Female	All	+1.053	<.001	11	view →
STAD	Male	II,III,IV	+1.269	<.001	8	view →
LUSC	Male	II,III,IV	+0.871	<.001	7	view →
LIHC	Female	All	+0.863	<.001	7	view →
UCEC	All	All	−1.292	<.001	6	view →
BRCA	Female	All	−0.558	<.001	6	view →
CHOL	All	All	+2.040	<.001	4	view →
KICH	Female	All	−1.325	<.001	3	view →
BLCA	Female	All	+0.868	.016	3	view →
ESCA	Male	All	+1.358	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ADCY3–HNSC

Open the HNSC breakdown →