ADCY3

Across TCGA patient cohorts, ADCY3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY3-associated genes across cancer lineages are ATM, MSH6, and Notch1. Each is linked with ADCY3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY3-to-partner and partner-to-ADCY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADCY3-low versus ADCY3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY3→partner) and Y-score (partner→ADCY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.525	-2.893	<.001	.001	3	3
UCEC	MSH6 →	-0.347	-1.584	.001	.015	3	2
UCEC	Notch1 →	+0.120	+1.817	.008	.015	3	2
UCEC	PDCD4 →	-0.408	-1.906	.007	.014	3	2
UCEC	c-Kit →	-0.215	-2.321	.004	<.001	3	2
COAD	4E-BP1 →	+0.260	+2.178	.011	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by ADCY3 expression — UCEC

Explore this box plot interactively →