ADCY3

Across TCGA cell cohorts, ADCY3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,506 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible ADCY3-associated GO terms across cancer lineages are Transcription initiation at RNA polymerase I promoter, Metaphase/anaphase transition of mitotic cell cycle, and Metaphase/anaphase transition of cell cycle. Each is linked with ADCY3 in more than 12 cancer types. Because this analysis shows association rather than direction, both ADCY3-to-partner and partner-to-ADCY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription initiation at RNA polymerase I promoter grouped by ADCY3-low versus ADCY3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY3→partner) and Y-score (partner→ADCY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transcription initiation at RNA polymerase I promoter →	+0.102	+0.894	<.001	<.001	3	13
SOFT_TISSUE	Metaphase/anaphase transition of mitotic cell cycle →	+0.159	+1.328	<.001	<.001	3	12
BREAST	Metaphase/anaphase transition of cell cycle →	+0.131	+1.629	<.001	<.001	2	12
PANCREAS	Establishment of spindle orientation →	+0.103	+1.153	<.001	<.001	3	11
PANCREAS	Mitotic sister chromatid segregation →	+0.117	+1.286	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Nuclear export →	+0.071	+0.917	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,506 associations by consensus.

Transcription initiation at RNA polymerase I promoter by ADCY3 expression — LARGE_INTESTINE

Explore this box plot interactively →