ADCY3

Across TCGA cell cohorts, ADCY3 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADCY3-associated genes across cancer lineages are OR2V2, DIPK1C, and MSGN1. Each is linked with ADCY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY3-to-partner and partner-to-ADCY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2V2 grouped by ADCY3-low versus ADCY3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY3→partner) and Y-score (partner→ADCY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR2V2 →	+0.029	+2.576	.006	.002	3	2
PANCREAS	DIPK1C →	+0.025	+4.491	<.001	.003	3	1
BONE	MSGN1 →	+0.100	+4.169	<.001	.008	3	1
BONE	TRIM64 →	+0.005	+4.169	<.001	.008	3	1
CNS	CYSLTR2 →	+0.231	+3.307	<.001	.008	3	1
CNS	LRRC10 →	+0.012	+2.730	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

OR2V2 by ADCY3 expression — BLOOD_Leukemia

Explore this box plot interactively →