ADCY2

Across TCGA cell cohorts, ADCY2 mutation is significantly associated with the RNA expression of many other genes, with 154 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY2-associated genes across cancer lineages are AMELY, OR2M3, and KRT222. Each is linked with ADCY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY2-to-partner and partner-to-ADCY2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMELY grouped by ADCY2-low versus ADCY2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY2→partner) and Y-score (partner→ADCY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AMELY →	+0.036	+3.273	<.001	.004	3	2
STOMACH	OR2M3 →	+0.200	+4.285	<.001	.007	3	2
SKIN	KRT222 →	+0.488	+3.781	.003	.003	3	2
LARGE_INTESTINE	ACTR6 →	+0.652	+2.351	<.001	.001	3	2
PANCREAS	SERPINA12 →	+0.010	+4.029	<.001	.007	3	1
OESOPHAGUS	C22orf31 →	+0.094	+3.906	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 154 associations by consensus.

AMELY by ADCY2 expression — OESOPHAGUS

Explore this box plot interactively →