ADCY1

Across TCGA patient cohorts, ADCY1 mutation is significantly associated with the RNA expression of many other genes, with 6,631 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY1-associated genes across cancer lineages are RBFA, CEP76, and PINK1-AS. Each is linked with ADCY1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADCY1-to-partner and partner-to-ADCY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBFA grouped by ADCY1-low versus ADCY1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY1→partner) and Y-score (partner→ADCY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RBFA →	+0.450	+2.526	<.001	.009	3	4
COAD	CEP76 →	+0.450	+3.645	.001	.001	3	4
COAD	PINK1-AS →	+0.673	+3.489	<.001	.002	3	4
COAD	EIF2B2 →	+0.371	+3.275	.001	.007	3	4
UCEC	SMU1 →	+0.381	+2.035	<.001	<.001	3	4
UCEC	CDCA8 →	+0.642	+1.412	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,631 associations by consensus.

RBFA by ADCY1 expression — COAD

Explore this box plot interactively →