ADCY1

Across TCGA cell cohorts, ADCY1 mutation is significantly associated with the RNA expression of many other genes, with 609 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCY1-associated genes across cancer lineages are PCDH11Y, KCNA6, and STUB1. Each is linked with ADCY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY1-to-partner and partner-to-ADCY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by ADCY1-low versus ADCY1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY1→partner) and Y-score (partner→ADCY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.012	+4.087	<.001	.009	3	2
LUNG_SCLC	KCNA6 →	+0.005	+2.647	<.001	.003	3	2
LARGE_INTESTINE	STUB1 →	+0.328	+3.169	.008	.009	3	2
LARGE_INTESTINE	GRPEL1 →	+0.429	+2.244	.003	.003	3	2
LARGE_INTESTINE	ABHD5 →	+0.541	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	EXOSC9 →	+0.602	+3.169	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 609 associations by consensus.

PCDH11Y by ADCY1 expression — URINARY_TRACT

Explore this box plot interactively →