ADCK5

Across TCGA cell cohorts, ADCK5 mutation is significantly associated with the RNA expression of many other genes, with 1,631 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCK5-associated genes across cancer lineages are ZIC5, FAXC, and COX11. Each is linked with ADCK5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCK5-to-partner and partner-to-ADCK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by ADCK5-low versus ADCK5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCK5→partner) and Y-score (partner→ADCK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZIC5 →	+1.000	+2.584	<.001	.002	3	2
LARGE_INTESTINE	FAXC →	+1.274	+2.158	<.001	.004	3	2
LARGE_INTESTINE	COX11 →	+0.574	+3.087	.003	.006	3	2
LARGE_INTESTINE	FBXW10 →	+0.165	+2.076	.002	.004	3	2
LARGE_INTESTINE	ZNF286A →	+0.829	+2.459	<.001	.006	3	2
BLOOD_Leukemia	RIMS4 →	+0.227	+3.675	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,631 associations by consensus.

ZIC5 by ADCK5 expression — LARGE_INTESTINE

Explore this box plot interactively →