ADCK1

Across TCGA patient cohorts, ADCK1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCK1-associated genes across cancer lineages are Shc_pY317, Ku80, and PCNA. Each is linked with ADCK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCK1-to-partner and partner-to-ADCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ADCK1-low versus ADCK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCK1→partner) and Y-score (partner→ADCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.172	-2.584	.015	.011	3	3
UCEC	Ku80 →	+0.278	+2.598	.011	.006	3	2
UCEC	PCNA →	+0.267	+2.321	.007	.034	3	2
UCEC	ASNS →	+0.625	+3.169	<.001	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.549	+2.189	.047	.034	3	2
UCEC	Di-Ras3 →	-0.191	-3.308	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Shc_pY317 by ADCK1 expression — UCEC

Explore this box plot interactively →