ADAP1

Across TCGA cell cohorts, ADAP1 mutation is significantly associated with the mutation status of many other genes, with 914 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ADAP1-associated genes across cancer lineages are RPRD2, GPC2, and STX11. Each is linked with ADAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAP1-to-partner and partner-to-ADAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPRD2 grouped by ADAP1-low versus ADAP1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAP1→partner) and Y-score (partner→ADAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPRD2 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	GPC2 →	+4.772	+5.339	.004	.004	1	3
OVARY	STX11 →	+4.415	+4.977	.007	.007	1	3
BREAST	BCLAF1 →	+4.297	+4.857	.009	.009	1	2
OVARY	DPF1 →	+5.415	+5.415	.004	.004	1	2
OVARY	ACP3 →	+4.415	+4.977	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 914 associations by consensus.

RPRD2 by ADAP1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →