ADAP1

Across TCGA pan-cancer cohorts, ADAP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADAP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADAP1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAP1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, STAD, and KIRP are the cancer types where ADAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−1.371	<.001	12	view →
STAD	Male	III,IV	+2.059	<.001	9	view →
KIRP	All	All	−0.871	<.001	7	view →
HNSC	All	All	+0.614	<.001	6	view →
BRCA	Female	All	+0.467	<.001	6	view →
COAD	All	II,III,IV	+0.426	.002	6	view →
CHOL	All	All	+2.945	<.001	5	view →
ESCA	All	II,III,IV	+3.215	.007	4	view →
LUSC	All	All	−0.536	<.001	4	view →
THCA	All	All	+0.300	.004	3	view →
BLCA	Male	All	+0.566	.044	2	view →
PRAD	All	All	−0.279	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADAP1–KIRC

Open the KIRC breakdown →