ADAMTS8

Across TCGA pan-cancer cohorts, ADAMTS8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADAMTS8 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher ADAMTS8 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADAMTS8 expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

READ, LUAD, and LIHC are the cancer types where ADAMTS8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	DFS	Median	All	0.082	0.799	<.001	23	view →
LUAD	DFS	Median	All	0.098	0.768	<.001	12	view →
LIHC	DFS	Median	II,III,IV	0.044	0.427	<.001	6	view →
BLCA	DFS	Median	II,III,IV	1.000	0.500	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ADAMTS8–READ (DFS)

Open the READ breakdown →