ADAMTS8

Across TCGA pan-cancer cohorts, ADAMTS8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADAMTS8 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ADAMTS8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADAMTS8 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where ADAMTS8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.834	0.996	.011	12	view →
UCEC	OS	Median	III,IV	0.366	0.982	.038	8	view →
PDAC	DFS	Median	II,III,IV	0.263	0.849	.038	6	view →
LSCC	OS	Quartile	III,IV	0.943	0.561	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ADAMTS8–LUAD (DFS)

Open the LUAD breakdown →