ADAMTS8

Across TCGA cell cohorts, ADAMTS8 RNA expression is significantly associated with the go_rna of many other GO terms, with 910 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ADAMTS8-associated GO terms across cancer lineages are Respiratory electron transport chain, Negative regulation of mRNA metabolic process, and Cytoplasmic translation. Each is linked with ADAMTS8 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADAMTS8-to-partner and partner-to-ADAMTS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Respiratory electron transport chain grouped by ADAMTS8-low versus ADAMTS8-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS8→partner) and Y-score (partner→ADAMTS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Respiratory electron transport chain →	+0.059	+0.063	.002	.005	3	6
LUNG_SCLC	Negative regulation of mRNA metabolic process →	+0.058	+0.794	.001	.002	3	5
PANCREAS	Cytoplasmic translation →	+0.061	+0.072	<.001	.008	2	6
UPPER_AERODIGESTIVE_TRACT	Purine nucleotide biosynthetic process →	+0.065	+0.077	<.001	.005	3	5
LUNG_SCLC	Nucleoside triphosphate biosynthetic process →	+0.071	+0.771	.007	.005	3	5
LUNG_SCLC	Purine nucleoside triphosphate biosynthetic process →	+0.093	+0.818	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 910 associations by consensus.

Respiratory electron transport chain by ADAMTS8 expression — URINARY_TRACT

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