ADAMTS6

Across TCGA patient cohorts, ADAMTS6 mutation is significantly associated with the RNA expression of many other genes, with 5,011 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS6-associated genes across cancer lineages are RNU6-787P, TPPP3, and AP3S1. Each is linked with ADAMTS6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS6-to-partner and partner-to-ADAMTS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-787P grouped by ADAMTS6-low versus ADAMTS6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS6→partner) and Y-score (partner→ADAMTS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-787P →	+0.266	+2.679	<.001	.001	3	3
UCEC	TPPP3 →	-1.194	-3.000	.002	<.001	3	3
UCEC	AP3S1 →	+0.500	+1.678	<.001	<.001	3	3
UCEC	ALAS1 →	+0.404	+1.505	.001	.001	3	3
UCEC	TTC22 →	-0.741	-2.201	<.001	<.001	3	3
UCEC	DAZAP1 →	+0.326	+1.710	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,011 associations by consensus.

RNU6-787P by ADAMTS6 expression — LUSC

Explore this box plot interactively →