ADAMTS6

Across TCGA pan-cancer cohorts, ADAMTS6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ADAMTS6 data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher ADAMTS6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS6 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

MESO, KIRP, and STAD are the cancer types where ADAMTS6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.395	0.685	<.001	97	view →
KIRP	DFS	Tertile	II,III,IV	0.148	0.580	.002	94	view →
STAD	OS	Median	All	0.491	0.658	<.001	92	view →
SKCM	OS	Median	All	0.843	0.714	<.001	92	view →
THCA	DFS	Tertile	II,III,IV	0.580	0.870	.010	44	view →
COAD	DFS	Tertile	All	0.365	0.599	.001	42	view →
BLCA	OS	Tertile	All	0.537	0.773	<.001	39	view →
ACC	OS	Tertile	II,III,IV	0.625	0.939	.004	36	view →
SCLC	DFS	Quartile	All	0.487	0.103	.004	35	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	32	view →
UCS	DFS	Median	IV	0.909	0.416	.008	30	view →
LUAD	DFS	Tertile	All	0.328	0.353	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ADAMTS6–MESO (OS)

Open the MESO breakdown →