ADAMTS6

Across TCGA patient cohorts, ADAMTS6 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS6-associated genes across cancer lineages are ATM, Fibronectin, and p38-MAPK_pT180_Y182. Each is linked with ADAMTS6 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS6-to-partner and partner-to-ADAMTS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADAMTS6-low versus ADAMTS6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS6→partner) and Y-score (partner→ADAMTS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.512	-3.156	<.001	<.001	3	4
LUSC	Fibronectin →	+0.494	+2.331	.023	.019	3	2
LUSC	p38-MAPK_pT180_Y182 →	-0.661	-3.321	<.001	.009	3	2
LUSC	PDK1_pS241 →	-0.159	-2.312	.015	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.119	-1.571	.017	.002	3	2
UCEC	p70-S6K_pT389 →	-0.124	-1.584	.029	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ATM by ADAMTS6 expression — UCEC

Explore this box plot interactively →