ADAMTS6

Across TCGA cell cohorts, ADAMTS6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,386 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADAMTS6-associated GO terms across cancer lineages are Regulation of establishment of T cell polarity, Actin filament depolymerization, and Regulation of protein K48-linked ubiquitination. Each is linked with ADAMTS6 in more than 12 cancer types. Because this analysis shows association rather than direction, both ADAMTS6-to-partner and partner-to-ADAMTS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of establishment of T cell polarity grouped by ADAMTS6-low versus ADAMTS6-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS6→partner) and Y-score (partner→ADAMTS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of establishment of T cell polarity →	+0.338	+2.425	<.001	.001	3	13
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.208	+2.060	<.001	<.001	3	12
PANCREAS	Regulation of protein K48-linked ubiquitination →	+0.118	+1.240	<.001	<.001	3	12
LIVER	Negative regulation of cell cycle G1/S phase transition →	+0.107	+1.801	.001	.004	3	12
SKIN	Positive regulation of collagen biosynthetic process →	+0.176	+1.102	<.001	<.001	3	12
BONE	Positive regulation of cell-substrate junction organization →	+0.179	+1.344	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,386 associations by consensus.

Regulation of establishment of T cell polarity by ADAMTS6 expression — LIVER

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