ADAMTS6

Across TCGA cell cohorts, ADAMTS6 mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS6-associated genes across cancer lineages are Mirin, UNC0642, and AZD5438. Each is linked with ADAMTS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS6-to-partner and partner-to-ADAMTS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by ADAMTS6-low versus ADAMTS6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS6→partner) and Y-score (partner→ADAMTS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.377	+2.646	.047	.047	3	1
LARGE_INTESTINE	UNC0642 →	+0.199	+2.658	.034	.043	3	1
LARGE_INTESTINE	AZD5438 →	+0.505	+2.777	.040	.038	3	1
LARGE_INTESTINE	GSK2801 →	+0.362	+2.649	.022	.046	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.310	+2.649	.028	.046	2	1
LARGE_INTESTINE	BDF00022089a →	+0.320	+2.649	.039	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Mirin by ADAMTS6 expression — LARGE_INTESTINE

Explore this box plot interactively →