ADAMTS5

Across TCGA patient cohorts, ADAMTS5 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS5-associated genes across cancer lineages are JNK_pT183_Y185, 4E-BP1, and INPP4B. Each is linked with ADAMTS5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS5-to-partner and partner-to-ADAMTS5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ADAMTS5-low versus ADAMTS5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS5→partner) and Y-score (partner→ADAMTS5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.161	-2.137	<.001	<.001	3	4
SKCM	4E-BP1 →	+0.347	+2.321	.022	.035	3	4
UCEC	INPP4B →	-0.195	-1.459	.034	.011	3	4
STAD	beta-Catenin →	+0.514	+1.700	.041	.038	3	3
STAD	BRCA2 →	-0.110	-2.066	.026	.005	2	4
STAD	cIAP →	+0.116	+2.087	.020	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

JNK_pT183_Y185 by ADAMTS5 expression — UCEC

Explore this box plot interactively →