ADAMTS4

Across TCGA patient cohorts, ADAMTS4 mutation is significantly associated with the RNA expression of many other genes, with 3,815 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS4-associated genes across cancer lineages are MMGT1, MTMR9, and KCTD9. Each is linked with ADAMTS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAMTS4-to-partner and partner-to-ADAMTS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMGT1 grouped by ADAMTS4-low versus ADAMTS4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS4→partner) and Y-score (partner→ADAMTS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MMGT1 →	+0.656	+3.507	.009	.002	3	3
SKCM	MTMR9 →	+0.584	+2.591	.005	.006	3	3
SKCM	KCTD9 →	+0.814	+3.488	.002	.002	3	3
UCEC	PPP3CC →	+0.626	+2.080	<.001	<.001	3	3
UCEC	APTX →	+0.325	+2.091	<.001	<.001	3	3
UCEC	LLPH →	+0.497	+2.101	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,815 associations by consensus.

MMGT1 by ADAMTS4 expression — SKCM

Explore this box plot interactively →