ADAMTS4

Across TCGA pan-cancer cohorts, ADAMTS4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ADAMTS4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADAMTS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAMTS4 is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where ADAMTS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAMTS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.396	<.001	11	view →
HNSC	All	III,IV	+1.455	<.001	11	view →
COAD	Female	All	+1.407	<.001	6	view →
BRCA	Female	All	+1.073	<.001	6	view →
LIHC	All	II,III,IV	+0.772	.002	4	view →
READ	All	All	+1.656	.027	3	view →
BLCA	All	All	−1.392	.016	2	view →
STAD	Male	II,III,IV	+1.314	.008	2	view →
KIRP	Male	All	−0.942	.020	2	view →
UCEC	All	All	−0.892	.045	2	view →
KICH	All	III,IV	−1.861	.023	1	view →
CHOL	All	All	+1.105	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ADAMTS4–KIRC

Open the KIRC breakdown →