ADAMTS4

Across TCGA patient cohorts, ADAMTS4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS4-associated genes across cancer lineages are GAPDH, beta-Catenin, and EGFR_pY1173. Each is linked with ADAMTS4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS4-to-partner and partner-to-ADAMTS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ADAMTS4-low versus ADAMTS4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS4→partner) and Y-score (partner→ADAMTS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.742	+3.182	<.001	.009	3	4
COAD	beta-Catenin →	-0.840	-2.450	.003	.020	3	3
UCEC	EGFR_pY1173 →	+0.067	+1.196	.015	.043	3	3
UCEC	mTOR_pS2448 →	-0.213	-3.074	<.001	<.001	3	3
UCEC	Rictor_pT1135 →	-0.086	-1.736	.015	.007	3	3
UCEC	Shc_pY317 →	-0.187	-2.662	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

GAPDH by ADAMTS4 expression — COAD

Explore this box plot interactively →