ADAMTS4

Across TCGA cell cohorts, ADAMTS4 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAMTS4-associated genes across cancer lineages are VWC2L, IQCF5, and SPP2. Each is linked with ADAMTS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS4-to-partner and partner-to-ADAMTS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by ADAMTS4-low versus ADAMTS4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS4→partner) and Y-score (partner→ADAMTS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.008	+3.924	<.001	<.001	3	2
BLOOD_Leukemia	IQCF5 →	+0.067	+4.201	<.001	<.001	3	2
BLOOD_Lymphoma	SPP2 →	+0.715	+5.247	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	PRR23C →	+0.006	+4.736	<.001	.009	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
OVARY	RBMY1A1 →	+0.143	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

VWC2L by ADAMTS4 expression — BLOOD_Leukemia

Explore this box plot interactively →